For example, THBS1 (stressed AD3), ADGRE5 (pan-immune) and NAMPT (multicellular), which are emergent triggers of insulin resistance32, immune glycolytic metabolism33 and inflammation34, were all amplified in obesity and reversed by WL (Fig. 4h and Extended Data Fig. 8h). This evidence concerns the gene NAMPT and obesity due to melanocortin 4 receptor deficiency.