BRAF and spindle cell sarcoma: Open biopsy of the primary lesion revealed a high-grade primitive spindle cell sarcoma with pleomorphism; sequencing of the tumor specimen via the Johns Hopkins Molecular Diagnostic Laboratory in-house next-generation sequencing (NGS) detected two DICER1 variants (p.E1813D and p.M1428fs) and a BRAF p.V600E mutation (“Primary” in Table 1).