Isogenic TP53mut AML cell line clones with complete loss (M14-Mut1, M14-Mut3) or missense-like mutations (M14-Mut2, M14-Mut4) of the p53 protein were developed using CRISPR/Cas9 editing of the AML cell line, MOLM14, with published guides [33, 34] and single cell cloning via serial dilution. Here, TP53 is linked to acute myeloid leukemia.