Herein, we studied the genomic determinants of therapy response in ETV6::RUNX1 leukemia by integrative analysis of array-based copy number analysis (CNA), whole genome (WGS) and targeted DNA sequencing, as well as sequencing of the transcriptome, in a cohort of patients stratified based on the therapy response to contemporary induction treatment. This evidence concerns the gene RUNX1 and leukemia.