This region that includes the ETV6 locus typically encompassed a larger segment beyond the translocation breakpoints, notably including the well-known oncogene KRAS, and the EMP1 gene locus, whose deletion has been shown to sensitize cells to prednisolone and high expression associated with poor event-free survival (EFS) in B-ALL [50, 51]. This evidence concerns the gene EMP1 and acute lymphoblastic leukemia.