GCK and neoplasm: To investigate whether the glucuronidation pathway is essential for trametinib resistance in byn > RAP tumours, we used hindgut-targeted knockdown to reduce the activity of key glucuronidation pathway enzymes including Hexokinase C (Hex-C; human ortholog: GCK), UDP-glucose Pyrophosphorylase (UGP; UGP2), Sugarless (Sgl; UDP-glucose 6-dehydrogenase, UDGH), and Glucuronyltransferase P (GlcAT-P).