Analyzing gene regulatory networks in GTEx lung samples, we found several genes with known relevance to cancer incidence and prognosis that were differentially targeted by TFs with age, including proto-oncogenes AKT1, ERBB3 and MYCN. Using pathway enrichment analysis, we saw a clearer picture of how age affects cancer-related processes in non-cancerous lung tissue, including altered regulation of intracellular adhesion, cell proliferation, and immune response. The gene discussed is ERBB3; the disease is cancer.