For comparison, it should be noted that, non-cancer genes (that is, genes not annotated as oncogene or TSG in the COSMIC database) are also increasingly targeted by TFs with age (p value of Wilcoxon rank sum test is 2.2e-16), meaning that the gene regulatory networks inferred for individuals in GTEx, increase in TF regulatory density as the age of the individual increases. Here, TF is linked to cancer.