We performed gene set enrichment analysis (GSEA) with genes, ranked by how much their targeting patterns change with age, and found (Fig. 3 leftmost column) that biological pathways associated with intracellular adhesion and cell proliferation, cell growth, and death have increasing TF targeting with age, including pathways annotated to adherens junction, apoptosis, hematopoietic cell lineage, cell adhesion molecules, and pathways in cancer. Here, TF is linked to cancer.