In brief, METTL3-modificatory m6A regulates the interaction of PANC754 with PSPC1 and H3K4me1 to form ncRNA/RBP/histone repression complex at gene promoter region to mediate the “Don’t eat me” LGALS7 signaling pathway, thereby exerting tumor-suppressing effects against CRC (Fig. 6G). Here, METTL3 is linked to neoplasm.