The mechanisms are that the nuclear-located PANC754 expression is regulated by m6A modification via METTL3 enzyme, which binds with its RBP PSPC1, then interacts with H3K4me1 to form ncRNA/RBP/histone repression complex inhibits immune evasive molecule LGALS7 and leads to suppress CRC progress (Fig. 6G). This evidence concerns the gene METTL3 and colorectal carcinoma.