A recent study reported that lactylation of MRE11 and NBS1 leads to resistance to platinum drugs and poly (ADP-ribose) polymerase (PARP) inhibitors via activation of the HR repair process in colon cancer and gastric cancer.52,53 According to the lactylome results of the present study, no significant differences in MRE11 and NBS1 lactylation were noted between EPI-resistant and nonresistant cells. Here, MRE11 is linked to malignant colon neoplasm.