GDPD5 and amyotrophic lateral sclerosis: Interestingly, GDE2 is found to aberrantly accumulate in neurons of the postmortem brain of patients with AD, ALS–FTD, and ALS, and consistent with disrupted GDE2 function, GPI-anchored protein release is reduced in AD and ALS (Nakamura et al., 2021; Westerhaus et al., 2022).