Prolyl-tRNA synthetase (PRS) conjugates proline to tRNA during collagen translation.171DWN12088, a PRS inhibitor, therapeutically reduced bleomycin-induced fibrosis in mice, which has led to a current phase II RCT to evaluate its safety and efficacy in IPF (identifier: NCT05389215).171. This evidence concerns the gene WNK3 and fibrosis.