GNRH1 and ovarian hyperstimulation syndrome: It should be noted that in our trial the cut-off for using a GnRH agonist trigger as a preventive intervention for early OHSS (25 follicles, ≥12 mm diameter) was higher than the threshold often used in clinical practice (18–19 follicles, ≥11 mm diameter) (Papanikolaou et al., 2006; Griesinger et al., 2016).