The capacity of exogenous DNase I to clear not only NET-deposited injurious ecDNA but also DNA deposited from all forms of cell death reported in anti-MPO GN (necroptosis, apoptosis, and necrosis) was tested in a 20-day murine model of actively induced autoimmune anti-MPO GN, which shows many of the hallmarks of human disease (20, 36, 44). Here, MPO is linked to ganglioneuroma.