As anti-MPO antibodies are important in activating neutrophils in MPO-ANCA GN, the therapeutic efficacy of DNase I shown in the 20-day T cell–mediated model of anti-MPO GN was also tested in a model of anti-MPO GN induced by transfer of anti-MPO antibodies into mice primed with LPS (40). This evidence concerns the gene MPO and ganglioneuroma.