TNFSF12 and leukemia: Despite the limitations of spatial transcriptomic technology and the limited sample size, we show that integrating complex single-cell proteogenomic analysis with spatial-temporal multiomic analysis in patients with AML is feasible and may lead to a deeper understanding of interactions between leukemia cells and immune cells in the bone marrow niche, as evidenced by our finding of the shifts in cell composition in leukemia neighborhood and leukemia cell–mediated TWEAK signaling.