Unexpectedly, the nearby naïve CD4 T cells (Fig. 5, D and E) and DCs (Fig. 5, F and G) had significantly higher expression of TNFRSF12A, which codes for the corresponding receptor TWEAKR (also known as FN14 and CD266) than that of the same cell types at least 30 μm away from the closest leukemia cell. The gene discussed is TNFRSF12A; the disease is leukemia.