Moreover, ten proteins, such as homogentisate 1,2-dioxygenase, vitellogenic carboxypeptidase, 4-hydroxyphenylpyruvate dioxygenase, S-methyl-5-thioadenosine phosphorylase, and others (Table S5), were exclusively found in DIM, while four proteins, including pyruvate dehydrogenase E1 component subunit alpha (Fragment), cytochrome C oxidase assembly factor 3, and others (Table S6), were exclusively found in BPH. The gene discussed is HGD; the disease is benign prostatic hyperplasia.