In the present study, five proteins/enzymes (aspartate aminotransferase position 29–397 and position 56–424, AAEL010442-PA, 4-hydroxyphenylpyruvate dioxygenase and homogentisate 1,2-dioxygenase) which are involved in the synthesis of tyrosine were uniquely expressed in DIM and whereby only 2 of the proteins/enzymes (aspartate aminotransferase protein position 29–397 and aspartate aminotransferase protein position 57–424) were differentially expressed in BPH compared to control. The gene discussed is HPD; the disease is benign prostatic hyperplasia.