The structure of JUNV GPC within a virus membrane also serves as a reference for investigating inhibitors of virus infection, whose activity may be influenced by the GPC-membrane interface.38 While the pre-fusion state of the JUNV GPC in PV membranes appears broadly similar to those of membrane-extracted NWM or Old World mammarenavirus GPCs (Figure S10), the nuances of the membrane-embedded GPC structure may differ from those in detergent-solubilized complexes or in mutationally stabilized structures and are not captured by AlphaFold3 models (Figure S9). Here, GYPC is linked to viral infectious disease.