,23,24 The expression of PEX14, the core component of peroxisome translocon and the common peroxisome marker, is often downregulated with age,7,8,45 although contrary results were reported in mouse hippocampus where PEX14 was induced as an adaptive response to oxidative stress in aging and neurodegenerative disease model.46 The gene discussed is PEX14; the disease is neurodegenerative disease.