Disease presentation can be insidious, and many patients do not display typical cardiac symptoms or investigation findings (such as elevated serum cardiac biomarkers (troponin, B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP)), electrocardiographic (ECG) or echocardiographic abnormalities indicative of cardiac disease. The gene discussed is NPPB; the disease is heart disorder.