Additionally, IL‐1β and IL‐18 have been identified as pathogen‐associated alarmin cytokines that activate skin‐resident group 2 innate lymphoid cell (ILC2) and subsequently trigger Th2 cell‐mediated immune responses in AD [4, 58, 59, 60, 61, 62, 63, 64]. Here, IL18 is linked to Alzheimer disease.