The reduced production of IL‐6, IL‐8, IL‐10, and IL‐23 by the hypo‐responsive LC upon TLR ligation is consistent with previous studies on tolerance and tolerogenic DC [36, 52], and in ex vivo skin of AD, TLR2‐induced IL‐6, and IL‐10 was reduced as well [22]. This evidence concerns the gene TLR2 and Alzheimer disease.