The top downregulated genes included protease inhibitor Itih2, glycosyltransferase B3gnt5, as well as Eph receptor 6 (Ephb6) and phospholipase Pla2g4c, found to be overexpressed in a colon cancer cell line and human colon cancer tissues (53, 54). The gene discussed is ITIH2; the disease is malignant colon neoplasm.