For the Phosphoinositide‐3‐Kinase Regulatory Subunit 2 (PIK3R2) gene, studies have found that biotransformed bear bile powder regulates arginine biosynthesis through the FXR/PXR‐PI3K‐AKT‐NOS3 axis to improve diet‐induced NAFLD in mice [16]. This evidence concerns the gene AKT1 and metabolic dysfunction-associated steatotic liver disease.