The results showed that the expression of Rab5a, Rab7a, EHD1, and ARF6 was significantly upregulated in the HLECs exposed to direct Akata cell contact compared to the other two EBV infection strategies, and the difference was statistically significant (P < 0.001, Fig. 6). The gene discussed is RAB7A; the disease is Epstein-Barr virus infection.