IFNG and infection: Both groups A and B had upregulated DEGs that showed a significant overlap with the characteristic pathways “inflammatory response,” “interferon gamma response,” and “interferon alpha response.” However, the DEGs differed between the two groups in the hallmarks that showed gene patterns for “unfolded protein response," “coagulation," “complement,” and “E2F targets.” DEGs with a significant overlap in these hallmark pathways were mainly expressed by patients in Group B (imprinted by previous infection).