Lastly, the heat shock protein A12A (HSPA12A, 10q25.3) is a member of the HSP70 family that regulates protein misfolding and plays a vital role in multiple neuropsychiatric conditions, including AD, major depressive disorder, bipolar disorder, and schizophrenia.116, 117. The gene discussed is HSPA12A; the disease is schizophrenia.