Dipeptidyl peptidase like 6 (DPP6, 7q36.2) influences neuronal hyperexcitability and synaptic growth and has been linked to amyotrophic lateral sclerosis (ALS) and developmental disorders,125, 126 while the microtubule actin cross‐linking factor 1 (MACF1, 1p34.3) protein [also known as actin crosslinking factor 7 (ACF7)] is essential for actin‐microtubule interaction and linked to neurodevelopmental and neurodegenerative diseases, including AD,127, 128 schizophrenia,129 PD,130 and bipolar disorder.131. Here, MACF1 is linked to Alzheimer disease.