The cell adhesion molecule 2 (CADM2, 3p12.1) plays critical roles in synaptic organization, glutamatergic signaling, and neuronal adhesion in dementia and psychiatric disorders,112, 113, 114 and sorbin and SH3 Domain Containing 1 (SORBS1, 10q24.1) plays an important role in insulin signaling and glucose homeostasis and has been linked to cognitive impairment.115. Here, INS is linked to Cognitive impairment.