LRRC56 and primary ciliary dyskinesia: One such protein, LRRC56, is a leucine-rich repeat protein whose role in ODA transport and assembly was first proposed based on studies of its algal homolog ODA8 in Chlamydomonas. Mutations in LRRC56 have been associated with chronic respiratory disease and laterality defects in humans, consistent with the clinical presentation of PCD (Alasmari et al., 2022; Asseri et al., 2023; Bonnefoy et al., 2018).