Specifically, TH+Kv7.2 expression was significantly lower than TH+Kv7.3 (−51.1%*, p=0.0378), TH+Kv7.4 (−55.9%, **p=0.0059), and TH+Kv7.5 (−55.1%, **p=0.0082), suggesting VTA dopamine neurons exhibit low basal Kv7.2 expression and a heightened expression during chronic neuropathic pain. The gene discussed is KCNQ2; the disease is Pain.