The FFC diet, which phenocopies the histological features of MASH and the associated metabolic dysfunction, has been shown to have the highest fidelity and relevance to human MASH.18,19 In this model, analyzing the protein expression and transcriptomes of hepatic CD4+ T cell populations, we identified CD4+ T cell populations in MASH that were enriched for signatures of Th1, Treg, and cytotoxic CD4+ T cells, which are novel in the context of MASH. This evidence concerns the gene CD4 and metabolic dysfunction-associated steatohepatitis.