LMNA and laminopathy: LMNA missense variants cause a wide range of diseases, collectively called laminopathies, including Emery-Dreifuss muscular dystrophy46 and dilated cardiomyopathy47 or, less commonly, Dunnigan-type familial partial lipodystrophy48, Charcot-Marie-Tooth neuropathy49, or progeroid syndromes50,51.