For example, the expression of Notch1 in precancerous lesions and gastric cancer tissues, such as intestinal epithelial chemotaxis and hyperdifferentiated intestinal-type gastric cancer, was significantly higher than that in normal tissues, suggesting that Notch1 plays a crucial role in promoting the transformation of epithelial chemotaxis in the gastric mucosa and maintaining the continuous proliferation of intestinal chemo epithelial cells (34, 48). This evidence concerns the gene NOTCH1 and gastric cancer.