NOTCH3 and gastric cancer: However, the Notch pathway and glandular differentiation are also closely related to gastric cancer cells, Notch1, Notch2, Notch3 in Notch receptors and Jagged1 and Jagged2 in Notch ligands have been found in human gastric cancer tissue samples, and each of them is expressed with different significance in physiological activities (47).