JAG1 and colorectal cancer: Increased Notch1 gene copy number has been found to be significantly associated with poorer survival in patients with advanced colorectal cancer, and tumors with upregulated Notch1 expression in a tumor xenograft model derived from patients with colorectal cancer show significant elevation of Notch1, JAG1 and NICD1, which may be ameliorated by targeting this patient population with Notch1 antibodies (26).