In malignant tumors such as lung cancer, the relationship between the Notch pathway and vascular endothelial growth factor (VEGF) is particularly close.Jagged1, as a ligand of the Notch pathway, can significantly upregulate the expression of VEGF and promote tumor neovascularization upon binding to Notch1, which in turn promotes tumor proliferation and metastasis (60). The gene discussed is VEGFA; the disease is cancer.