PTEN and acute lymphoblastic leukemia: (93) found that Notch signaling is activated in T-ALL, promotes the expression of the target gene HES, which inhibits the expression of PTEN, which is downregulated and promotes the activation of PI3K/Akt, thus inhibiting the apoptosis of tumor cells, and when a Notch signaling inhibitor is applied, it promotes the expression of PTEN and reverses the anti-apoptotic effect of PI3K/Akt and induces apoptosis.