NOTCH1 and neoplasm: In malignant tumors such as lung cancer, the relationship between the Notch pathway and vascular endothelial growth factor (VEGF) is particularly close.Jagged1, as a ligand of the Notch pathway, can significantly upregulate the expression of VEGF and promote tumor neovascularization upon binding to Notch1, which in turn promotes tumor proliferation and metastasis (60).