Increased Notch1 gene copy number has been found to be significantly associated with poorer survival in patients with advanced colorectal cancer, and tumors with upregulated Notch1 expression in a tumor xenograft model derived from patients with colorectal cancer show significant elevation of Notch1, JAG1 and NICD1, which may be ameliorated by targeting this patient population with Notch1 antibodies (26). The gene discussed is NOTCH1; the disease is neoplasm.