It was found that the expression of Notch1 in ovarian cancer tissues was significantly higher than that in matched normal ovarian tissues, while Notch1 was highly expressed in ovarian cancer cell lines A2780 and HO-8910, and the expression of Notch1 gradually increased with the poor differentiation of ovarian cancer tissues and the increase of FIGO stage. The gene discussed is NOTCH1; the disease is ovarian cancer.