LDHA and neoplasm: Modulation of LDHA expression or activity affects PDAC cell migration and globule growth, decreases metalloproteinases and cancer stem cell-like cell marker (i.e., CD133+) expression (55).LDHA overexpression decreased phosphorylation of the metabolic regulator AMPK and promoted downstream mTOR phosphorylation in PDAC cells, enhancing PDAC cell proliferation, tumor stem cell proliferation, invasion, and metastasis (56).