LncRNAs, in addition to having a role in PDAC development, also play an important role in GEM resistance, e.g., HIF1A-AS1 significantly up-regulates lncRNAs in GEM-R pancreatic cancer cells and triggers glycolysis-associated GEM resistance by regulating the translation of the justice gene HIF-1α (45). The gene discussed is HIF1A; the disease is familial pancreatic carcinoma.