Modulation of LDHA expression or activity affects PDAC cell migration and globule growth, decreases metalloproteinases and cancer stem cell-like cell marker (i.e., CD133+) expression (55).LDHA overexpression decreased phosphorylation of the metabolic regulator AMPK and promoted downstream mTOR phosphorylation in PDAC cells, enhancing PDAC cell proliferation, tumor stem cell proliferation, invasion, and metastasis (56). This evidence concerns the gene LDHA and cancer.