LDHA and neoplasm: When tumor growth exceeds its oxygen supply, upregulation of LDHA ensures ATP synthesis, increases resistance to oxidative stress by promoting DNA repair and NADPH production, and reduces ROS by inhibiting mitochondria, favoring Epithelial-Mesenchymal Transition(EMT) epithelial-mesenchymal transition and angiogenesis by starving neighboring cells for nutrients and evading the immune system to create space (57).