Dysregulated expression of DRP1, DRP1, and MFN2 has been observed in several types of cancers, including hepatocellular carcinoma (86), breast carcinoma (87), and lung carcinoma (88), DRP1 is significantly up-regulated in pancreatic cancer cells and tissues, whereas knockdown of DRP1 strongly induced apoptosis in PDAC cells. Here, DNM1L is linked to familial pancreatic carcinoma.