Having already proven that Mn-ZrMOF can synergistically enhance the antitumor effects of MW and that Mn-ZrMOF@DAC can induce the up-regulation of GSDM expression in bladder cancer, we will further explore whether Mn-ZrMOF@DAC can synergize with the antitumor effects of MW and induce pyroptosis in BLCA. Here, GSDMA is linked to bladder transitional cell carcinoma.