GSDME and neoplasm: In conjunction with previously verified mechanisms of Mn-ZrMOF+MW inducing ROS, this suggests that during Mn-ZrMOF@DAC+MW treatment, DAC loaded in Mn-ZrMOF@DAC can be released into tumor cells, up-regulating GSDME protein, and massive ROS production post-MW radiation can activate caspase-3.