Whole exome sequencing (WES) identified somatic pathogenic or likely pathogenic variants in WT1 and PRDM2 with deletions within ETV6, SETD2, ADD2, EZH2, PRDM2, and NF2. Germline WES revealed a missense variant of uncertain significant (VUS) in CHEK2. Analysis of microsatellite instability, tumor mutational burden, and chromosomal breakage was not performed. Here, PRDM2 is linked to neoplasm.