The MAPK signaling pathway is highly diverse, regulating many cellular functions from cell growth to tissue differentiation, and is sensitive to the downstream effects of reduced calcium signaling through its relation to the PLC-IP3-DAG pathway.31 Previous studies have linked multiple genes in the MAPK pathway to hypertension.32,33 and beta-adrenergic receptor polymorphisms to blood pressure variability and alterations in cardiac output,34 which is in line with our results. The gene discussed is HSPG2; the disease is hypertensive disorder.