The pathophysiology of CCD is mediated by TH1 and TH17, and elevated IL-17 and IL-23 levels.2 Mutations in TRAF3IP2 are thought to be associated with CCD.2 Histopathology is classically characterized by non-caseating granulomas and chronic lymphocytic inflammation at cutaneous locations that are non-contiguous with the gastrointestinal tract.8 This evidence concerns the gene TRAF3IP2 and Granuloma.