We analyzed the FOXM1 expression in publicly available single-cell gene expression data of SCLC patient samples, characterize its expression in multiple cell lines of SCLC (both human and murine), SCLC tissues from genetically engineered mouse model and patient samples, and demonstrated that FOXM1 could be a potential therapeutic target for SCLC. Here, FOXM1 is linked to small cell lung carcinoma.