Next, we wanted to validate our findings in vivo, and for this, a spontaneous mouse model of SCLC (RPM: RBfl/fl;TP53fl/fl;LSL-MYCT58A) was used, where we can perform conditional deletion of tumor suppressors RB1 and P53, and overexpression of MYC and it recapitulates human SCLC characteristics [37]. The gene discussed is RB1; the disease is small cell lung carcinoma.