Among them, MMP9 is particularly important, as its dysregulated expression is implicated in both physiological and pathological remodeling processes.(28) Overexpression of MMP9 has been linked to increased inflammation, fibrosis, and cardiovascular complications.(28–30) These findings, therefore, may contribute to a broader understanding of the mechanistic basis for sex-based differences observed in cardiovascular disease. This evidence concerns the gene MMP9 and cardiovascular disorder.