CRP and psychiatric disorder: CRP levels correlate strongly with other inflammatory cytokines, including interleukin (IL)-6, IL-1β, and tumor necrosis factor23–25, and show high correspondence with cerebrospinal fluid CRP (r = 0.855)26, potentially explaining why peripheral CRP concentration has been associated with structural brain alterations27,28 and various psychiatric disorders, including major depressive disorder29,30, bipolar disorder31, and schizophrenia32.