Findings suggestive of specific HES subtypes include rearrangement or mutation of the genes PDGFRA, PDGFRB, FGFR1, or JAK2, or evidence of clonal eosinophilia (M-HES subtype) and clonal T-cell population that produces eosinophil-promoting cytokines (L-HES subtype). This evidence concerns the gene JAK2 and hypereosinophilic syndrome.