Although the study of Hatzikotoulas et al. (2025[25]) included drug targets, only CYP26B1 (cytochrome P450 26B1) involved in the degradation and ALDH1A2 (aldehyde dehydrogenase 1A2) involved in the synthesis of all-trans-retinoic acid were reported as genes coding for metabolizing enzymes associated with hip or knee osteoarthritis. This evidence concerns the gene ALDH1A2 and osteoarthritis, knee.