ORAI1 and atrial fibrillation: Inhibitors such as CM4620 and Synta66 have been shown toeffectively block Orai1-mediated calcium influx, thereby preventing the triggercalcium transients that play a pivotal role in the initiation of AF [152, 153].Oxidative stress is one of the key factors contributing to the abnormalactivation of the CRAC channel, and its modulation may represent a potentialtherapeutic approach for AF [154, 155].