(2) B-type natriuretic peptide (BNP) or N-terminal (NT)-proBNP: BNP and itsprecursor N-terminal pro B-typenatriuretic peptide (NT-proBNP) help to diagnose and monitor heart failure by providinginformation about pressure within the heart’s chambers and overall cardiacperformance. The gene discussed is NPPB; the disease is heart failure.