In thepediatric population, myxomatous degeneration of cardiac valves has been linkedto genetic diseases such as trisomy 18, Noonan, Marfan, and Ehlers–Danlossyndrome, with a huge emphasis on the 6q25.1 gene deletion that expresses thetransforming growth factor (TGF)-beta-activated kinase 1/mitogen-activatedprotein kinase kinase kinase 7 (MAP3K7)-binding protein 2 (TAB2 gene)protein [19]. This evidence concerns the gene MAP3K7 and hereditary disease.