The regulation of Nav1.5 after myocardial ischemia is very complex.Through in-depth analysis of its genetic variation, signaling regulation and drugintervention strategies, it is expected that more precise and effectivearrhythmia treatment strategies will be realized in the future to reduce theincidence of SCD and improve the quality of survival of MI patients. The gene discussed is SCN5A; the disease is Schnyder corneal dystrophy.