ABCG1 and cardiovascular disorder: However, post-menopausal womenhave a similar incidence of cardiovascular diseases as males [59].17β-Estradiol upregulates ABCA1 and ATP-Binding Cassette Sub-Family GMember 1 (ABCG1) expression in VSMCs via the LXRα-dependent pathway,promoting the cholesterol outflow of VSMCs and thus inhibiting the generation ofVSMC-derived foam cells [41] (Table 1).