TRPV1 and migraine disorder: In contrast to the antinociceptive effects discussed above, both AEA and 2-AG are known agonists for pronociceptive, heat, and capsaicin-mediated transient receptor potential cation channel subfamily Vanilloid member 1 TRPV1 [98, 99], suggesting a possible role in initiating migraine attacks, in clear opposition to the effects on the cannabinoid receptors [100–102].