MLXIPL and diabetic kidney disease: Inducible knockdown of ChREBP in podocytes significantly reduced mitochondrial fragmentation and improved the renal phenotype in db/db mice, suggesting that lipid metabolic reprogramming may influence mitochondrial dynamics via modulation of mitochondrial lipid architecture (Li et al., 2023).In addition, abnormal remodeling of cardiolipin—a critical phospholipid of the inner mitochondrial membrane—has been implicated in mitochondrial dysfunction in DKD.