In addition, the levels of oxidative stress markers ROS, NOX4 and TXNIP decreased significantly and the level of MDA was reduced, accompanied by the upregulation of the activities of antioxidant enzymes SOD and GSH-PX in the renal tissues of the mice in the intervention group of Rg5, suggesting that Rg5 plays a synergistic role in anti-inflammatory and antioxidant effects through the regulation of oxidative stress and the cross-regulation of NLRP3/MAPK/NF-κB pathway, thus delaying DKD disease. The gene discussed is NFKB1; the disease is diabetic kidney disease.