Data analysis from the PRIDE study showed that NT-proBNP helped exclude CHF irrespective of renal function (negative predictive value 94% and 100% for patients with glomerular filtration rate <60 mL/min/1.73 m2 and ≥60 mL/min/1.73 m2, respectively), the cut-off value was 300 pg/mL [11]. This evidence concerns the gene NPPB and congestive heart failure.