There were 4 variables identified that were significantly associated with the progression to kidney failure in the final model, namely sex, proteinuria, estimated glomerular filtration rate (eGFR), and pathogenic variants in COL4A5. Based on the model risk stratification, the median age at kidney failure was 23, 30, and 61 years in the low-, intermediate-, and high-risk groups, respectively. The gene discussed is COL4A5; the disease is kidney failure.