CDKN1B and neoplasm: Expression difference of the miRNA-221 target mRNA CDKN1B in tumor tissue compared to adjacent non-tumor tissue was not significant, with a CDKN1B tumor tissue median ΔCt value of -4.45 (IQR ±5.65), non-tumor tissue median ΔCt value of -2.39 (IQR ±8.46), fold change 1.83 (IQR ±10.5), 0.54 times downregulation and p-value of 0.056 (Wilcoxon test, Figure 2A, Table 1).