Recent study has shown that IL-17RB is overexpressed in clinical HCC samples and its high expression correlates with poor patient prognosis (46).The IL-17 signaling pathway primarily consists of IL-17 family cytokines (such as IL-17A to F) and their corresponding receptors (including IL-17RA to IL-17RE). The gene discussed is IL17RA; the disease is hepatocellular carcinoma.