TSC2 and tuberous sclerosis: Tuberous sclerosis complex (TSC) is a multi-system disorder caused by pathogenic variants in TSC1 or TSC2 genes.1 The hallmark of brain MRIs in patients with TSC is the presence of tubers—a subtype of focal cortical dysplasias (FCD)—which cause a number of neurological and cognitive symptoms, including epilepsy in 85% of patients.1 Epilepsy is diagnosed in around 80% of patients before the age of two2 and is drug-resistant in 62%1 of the TSC patients.